About Sickle Cell

About Sickle Cell

About Sickle Cell

What is Sickle Cell Disease?

What is Sickle Cell Disease?

Sickle cell disease is a genetic blood disorder that affects how red blood cells carry oxygen throughout the body. Instead of being round and flexible, these cells become stiff and crescent-shaped (“sickle”-shaped), which can block blood flow and lead to severe pain and organ damage. It is a lifelong condition that can significantly impact both patients and their families.

Sickle cell disease is a genetic blood disorder that affects how red blood cells carry oxygen throughout the body. Instead of being round and flexible, these cells become stiff and crescent-shaped (“sickle”-shaped), which can block blood flow and lead to severe pain and organ damage. It is a lifelong condition that can significantly impact both patients and their families.

Sickle cell disease is a genetic blood disorder that affects how red blood cells carry oxygen throughout the body. Instead of being round and flexible, these cells become stiff and crescent-shaped (“sickle”-shaped), which can block blood flow and lead to severe pain and organ damage. It is a lifelong condition that can significantly impact both patients and their families.

Sickle cell disease affects individuals across many communities, though it is more common among people whose ancestry traces to regions such as Africa, the Middle East, the Mediterranean, and parts of Central and South America. In the United States, it impacts approximately 70,000 to 100,000 people. Many families affected by sickle cell disease also face systemic barriers to healthcare access, making support and awareness even more critical.

Sickle cell disease affects individuals across many communities, though it is more common among people whose ancestry traces to regions such as Africa, the Middle East, the Mediterranean, and parts of Central and South America. In the United States, it impacts approximately 70,000 to 100,000 people. Many families affected by sickle cell disease also face systemic barriers to healthcare access, making support and awareness even more critical.

Sickle cell disease affects individuals across many communities, though it is more common among people whose ancestry traces to regions such as Africa, the Middle East, the Mediterranean, and parts of Central and South America. In the United States, it impacts approximately 70,000 to 100,000 people. Many families affected by sickle cell disease also face systemic barriers to healthcare access, making support and awareness even more critical.

Signs and Symptoms

Signs and Symptoms

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  • Sickled cells block small blood vessels, causing pain


  • Ranges from mild to severe; may need medication, fluids, or hospitalization

Pain Episodes & Crises

Anemia

  • People with sickle cell disease, especially children, are at increased risk for harmful infections


Infections

  • Sickle cell disease can increase the risk of stroke, especially in children 


Stroke Risk

  • Infection or spleen enlargement can worsen anemia


  • Spleen complications may require a blood transfusion


Severe Anemia from

Spleen Problems

  • A serious complication of sickle cell disease


  • Chest pain, breathing problems, cough, fever, or low oxygen


Acute Chest Syndrome

  • Sickled cells block small blood vessels, causing pain


  • Ranges from mild to severe; may need medication, fluids, or hospitalization

Pain Episodes & Crises

Anemia

  • People with sickle cell disease, especially children, are at increased risk for harmful infections


Infections

  • Sickle cell disease can increase the risk of stroke, especially in children 


Stroke Risk

  • Infection or spleen enlargement can worsen anemia


  • Spleen complications may require a blood transfusion


Severe Anemia from

Spleen Problems

  • A serious complication of sickle cell disease


  • Chest pain, breathing problems, cough, fever, or low oxygen


Acute Chest Syndrome

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